https://www.informativejournals.com/journal/index.php/tjpls/issue/feedTropical Journal of Pharmaceutical and Life Sciences2025-01-29T22:27:55+0530Tropical Journal of Pharmaceutical and Life Scienceseditortjpls@gmail.comOpen Journal Systems<p align="justify"><strong>Tropical Journal of Pharmaceutical and Life Sciences-TJPLS Journal (ISSN : 2349-9818) </strong>is a Scholarly Double-Blind Peer-reviewed international journal which promotes the original work in field of pharmaceutical and life sciences. Necessity is the mother of invention and invention arises from researches. Therefore promoting researchers is way to solving the problems of humanity. Pharmacy is the field which is for serving the mankind and to relieve it from suffering. TJPLS accepts original research papers as well as review articles in the field of Pharmaceutical and Life Sciences.</p>https://www.informativejournals.com/journal/index.php/tjpls/article/view/170FORMULATION AND OPTIMIZATION OF GASTRO-RETENTIVE FLOATING TABLETS OF ENALAPRIL MALEATE AND LOSARTAN FOR ENHANCED BIOAVAILABILITY AND THERAPEUTIC EFFICACY2025-01-29T22:18:47+0530Rohit Jaiminikanchaya.jaimini@gmail.comDr. Manish Jaiminimanishjaimini@gmail.com<p>The objective of this study was to formulate and optimize gastro-retentive floating tablets of Enalapril Maleate and Losartan to enhance their bioavailability and therapeutic efficacy. These drugs, commonly used in the management of hypertension and heart failure, suffer from limited solubility and rapid gastric emptying, which reduce their effectiveness. Gastro-retentive floating tablets were developed using hydroxypropyl methylcellulose (HPMC K4M) and guar gum as release-controlling agents, with sodium bicarbonate and citric acid as effervescent agents to ensure buoyancy. Twenty formulations were prepared using the direct compression method and evaluated for critical parameters, including hardness, friability, swelling index, floating lag time, total floating time, and in-vitro drug release.<br>Preformulation studies confirmed the compatibility of the drugs with excipients, with no chemical interactions detected using FTIR spectroscopy. The micrometric properties of the powder blends demonstrated excellent flowability and compressibility, ensuring suitability for tablet manufacturing. All formulations showed acceptable weight variation, hardness, and friability. The floating lag time ranged from 4.3 to 5.1 minutes, and total floating times exceeded 8 hours for all batches. Drug content ranged from 96.79% to 99.57%, reflecting uniformity and accuracy in dosing.<br>In-vitro dissolution studies revealed sustained release profiles, with optimized formulations achieving over 90% cumulative drug release within 12 hours. Batch F7 demonstrated the best overall performance, with a high swelling index, minimal floating lag time, prolonged floating duration, and consistent drug release. These findings indicate that gastro-retentive floating tablets of Enalapril Maleate and Losartan can effectively address challenges associated with poor bioavailability and rapid gastric emptying, offering a promising approach for improved therapeutic outcomes and patient compliance.</p>2025-01-29T00:00:00+0530Copyright (c) 2025 Tropical Journal of Pharmaceutical and Life Sciences