Tropical Journal of Pharmaceutical and Life Sciences 2023-09-23T21:26:23+0530 Tropical Journal of Pharmaceutical and Life Sciences Open Journal Systems <p align="justify"><strong>Tropical Journal of Pharmaceutical and Life Sciences-TJPLS Journal (ISSN : 2349-9818) </strong>is a Double-Blind Peer-reviewed international journal which promotes the original work in field of pharmaceutical and life sciences. Necessity is the mother of invention and invention arises from researches. Therefore promoting researchers is way to solving the problems of humanity. Pharmacy is the field which is for serving the mankind and to relieve it from suffering. TJPLS accepts original research papers as well as review articles in the field of Pharmaceutical and Life Sciences.</p> Formulation and Evaluation of Paracetamol Tablet to Assess Binding Property of Limonia acidissima Pectin 2023-09-16T23:04:59+0530 Varsha C. Fegade Sachin B. Narkhede Rushabh Kumar <p>Plants acts as a major source of medicines and are used to formulate various pharmaceutical preparations. Apart from this they act as excellent pharmaceutical aids and excipients.Limonia acidissima is nutritious, easily available, cheap but underutilized fruit. The aim of present research is to isolate the pectin from dried fruit pulp of Limonia acidissima and to assess its binding property. Pectin was extracted by boiling dried fruit pulp powder with water for 7 hrs at pH 3.2 adjusted with citric acid and using ethanol as precipitating agent.&nbsp; Binding property of pectin was assessed using paracetamol as a model drug. Paracetamol granules were prepared by wet granulationmethod. Granules were prepared using starch as disintegrant, calcium carbonate as filler, talc as glidant, Magnesiumstearate as lubricant and varying concentration of pectin as binder and were compressed into respective tablets.A reference batch of starch as binder was prepared to carry out the comparative study and to assess the binding property of pectin. Total four batches of formulation were prepared using different concentrations of pectin. For each formulation pre compression and post compression studies were performed and compared to range asper pharmacopoeias. Tablets were evaluated based on Weight uniformity, Tablet Hardness, Friability, Disintegration and In vitro drug release. The results obtained for all pre-compression and post compression parameters were found within acceptable range of pharmacopoeias. Limonia acidissima pectin can act as excellent binder in dosage forms. In vitro dissolution studies were revealed that batch F3 showed 99.64 % of drug release. In pharmaceutical dosage form like tablet, Limonia acidissima pectin acts as an excellent binder since it is of natural origin and Limonia acidissima fruits were available easily at very low costand proved to be better alternative for synthetic binder.</p> 2023-09-16T00:00:00+0530 Copyright (c) 2023 Tropical Journal of Pharmaceutical and Life Sciences In-Vitro Evaluation of Antiulcer Activity of Ethanol Extract of Saponaria Officinalis 2023-09-16T23:22:36+0530 Ms. Sowmya B.A Dr. Satish Pavuluri <p>For the treatment and prevention of illnesses and disorders, medicinal plants are recognized to contain conventional therapeutic substances. This study examined the potential of ethanol extracts of <em>Saponaria officinalis </em>to block H+/K+ ATPase and neutralize acids in order to determine whether they may be utilized to cure ulcers. In traditional medicine, the <em>Saponaria officinalis</em> is used to treat gastrointestinal disorders and inflammation. The acidity of the extract at a 1500 mg/ml concentration was much lower than that of conventional aluminium hydroxide + magnesium hydroxide (500mg), falling to 5.33 from 12.7. The ethanol extract of <em>Saponaria officinalis</em> at a concentration of 100μg, showed maximum percentage of inhibition of 67.17±1.96% as compared to omeprazole 71.47±0.52%, demonstrated the highest percentage of inhibition of the H+/K+ - ATPase. The results of this study suggest that <em>Saponaria officinalis</em> ethanol extract contains substances that can block enzymes and neutralize acids, making it a potential alternative treatment for digestive issues.</p> 2023-09-16T00:00:00+0530 Copyright (c) 2023 Tropical Journal of Pharmaceutical and Life Sciences SYNTHESIS, DOCKING AND EVALUATION OF PYRIMIDINE DERIVATIVES AS ANTI-MALARIAL AGENTS 2023-09-17T04:43:50+0530 Amit Kumar Sen Rakesh Kr. Jat <p>Malaria is endmic disease of tropical and subtropical contries like India, Pakistan, Srilanka, Bangladesh, South Africa etc. There are lot of fatalities and causalities due to malaria every year. There are lot of drugs have been synthesized for controlling this intermittent fever like chloroquine, hydroxychloroquine, pamaquine, primaquine, artimisininine, sulphadoxine, pyrimethamine, dapsone. The pyrimidine derivative synthetic drugs like sulphadoxine and pyramethamine have potential role to treat malaria with fever side effects. The lead molecule is pyrimdine and various groups are attached to this nucleus for optimizing the activity of lead nucleus and its derivative to treat this dangerous disease.</p> <p>The main causative organisms are plasmodium falciparm, plasmodium vivex, plasmodium malariae and ovale that cause malaria in patient and transmitted in blood after bitting of female anopheles mosquito that act as vector for plasmodium species.</p> <p>The docking studies are also performed by software and proper lead compound is identified with docking studies. The synthesis of compounds were carried out in laboratories with&nbsp; microwave synthesis and newer techniques that are fast and less time consuming of better yield of products. Structure activities relationships are studied and optimum activities are obtained by replacing different functional groups and other groups.</p> 2023-09-22T00:00:00+0530 Copyright (c) 2023 Tropical Journal of Pharmaceutical and Life Sciences Synthesis, Characterisation and Anticancer Study of Acridine derivatives 2023-09-17T04:58:06+0530 Herole R A Rakesh Kumar Jat <p>Cancer is one of the global problem and a major cause for mortality. many treatment strategies are available for cancer treatment, still there is a scope for novel treatment to avoid serious side effects of existing therapy. Novel DNA binding agents are needed for effective treatment of cancers. In the field of&nbsp;antitumor&nbsp;DNA-intercalating agents, 9-aminoacridines play an important role due to their antiproliferative properties. Several cancer chemotherapeutics such as amsacrine and nitracrine have been developed as&nbsp;anticancer agents.In present study, a series of new acridine-based derivatives numbered 3a–3j were synthesized and their anticancer activity against A549 (Human, small cell Lung Carcinoma) cell line was evaluated by MTT Assay. Out of the screened compounds, compound 3b exhibited potent anticancer activity with IC50 78.04 µg/ml for lung cancer cell (A-549) line.Further in vivo study of newly synthesized acridine derivative can explore a ray of light in the field of anticancer drugs.</p> 2023-09-17T00:00:00+0530 Copyright (c) 2023 Tropical Journal of Pharmaceutical and Life Sciences In-Vitro Analysis of Ethanol Extract of Saponaria Officinalis for Antiurolithiatic Activity 2023-09-17T05:26:41+0530 Ms. Sowmya B A Dr. Satish Pavuluri <p>The goal of the current study was to assess <em>Saponaria officinalis </em>ethanol extracts' in-vitro anti-urolithiatic effectiveness as a potential natural therapy to combat adverse effects brought on by the use of contemporary synthetic medications. <em>S. officinalis</em> extracted with ethanol was put to the test for its ability to treat urolithiasis utilizing in vitro studies (nucleation, aggregation assays). This extract was evaluated and contrasted with the reference medication cystone at increasing concentrations of 200, 400, 600, 800, and 1000μg/ml. The extract's ability to suppress the growth of calcium oxalate crystals in preformed forms was evaluated. The results of the <em>S. officinalis</em> extract on the nucleation assay were significant and showed considerable inhibition 64.2%±0.5 compared to standard cystone drug 67.7%±0.8 at 1000μg/ml concentration. Additionally, the ethanol extract of <em>S. officinalis</em> showed significant inhibition in the aggregation assay with a difference of 74.2%±0.08 compared to cystone 76.7%±0.09 at 1000μg/ml concentration. At a dose level of 1000μg/ml, the ethanol extract of <em>S. officinalis</em> possesses anti-urolithiatic potentials in vitro. It is possible to further exploit the ethanol extract of <em>S. officinalis</em> as a potential anti-urolithiasis medication.</p> 2023-09-23T00:00:00+0530 Copyright (c) 2023 Tropical Journal of Pharmaceutical and Life Sciences