Tropical Journal of Pharmaceutical and Life Sciences <p align="justify"><strong>Tropical Journal of Pharmaceutical and Life Sciences-TJPLS Journal (ISSN : 2349-9818) </strong>is a peer reviewed international journal which promotes the original work in field of pharmaceutical and life sciences. Necessity is the mother of invention and invention arises from researches. Therefore promoting researchers is way to solving the problems of humanity. Pharmacy is the field which is for serving the mankind and to relieve it from suffering. TJPLS accepts original research papers as well as review articles&nbsp; in the field of Pharmaceutical&nbsp; and Life Sciences.</p> Jadoun Science Publishing Group India en-US Tropical Journal of Pharmaceutical and Life Sciences 2349-9818 A REVIEW ON ACRIDINE, XANTHENE AND ITS DERIVATIVES: SYNTHESIS, PHYSICAL AND PHARMACOLOGICAL PROPERTIES <p>Acridine derivatives are&nbsp;one of the oldest category of bioactive, globally used as anticancer, antiprotozoal agents and antibacterial. The class of acridine derivatives constitutes an interesting group of nitrogen-containing tricyclic compounds that caught the scientific group’s attention, mainly due to its wide range of pharmaceutical properties. The synthesis of new polycyclic acridine skeletons fused with a five or six-membered rings, have been extensively studied because they play important roles in some DNA-intercalating anticancer drugs. Benzoacridine derivatives have been recently synthesized by a number of methods via one-pot multi-component condensation reactions of dimedone, naphthylamines, and aldehydes in different conditions, for example, using triethylbenzylammonium chloride/H<sub>2</sub>O, ionic liquid, under microwave irradiation, or ultrasound irradiation. A xanthene is found to most multifaceted heterocyclic ring having as it is having variety of activity and utilization. Xanthine&nbsp;derivatives are medications used to treat bronchospasm caused by lung conditions such as&nbsp;asthma. Xanthenes dyes shows antiviral activity, anti-tubercular, anticancer, anti-microbial, malonate derivatives was having anti-spasmodic activity. Benzoxanthenes are tetracyclic dibenzopyrans with diverse biological and therapeutic properties such as antibacterial, antitumor, anti-inflammatory, antiviral, pesticidal activities, and antimalarial.</p> Herole RA Rakesh Kumar Jat Rajendra D Dighe Copyright (c) 2023 2022-12-27 2022-12-27 9 6 01 12 METHOD DEVELOPMENT AND VALIDATION OF ATAZANAVIR AND RITONAVIR IN THE DOSAGE FORM BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY <p>The present work describes a validated reverse phase high performance liquid chromatographic method for the estimation of Atazanavir and Ritonavir in the dosage form.The quantification was carried out using Sunfire C18 (250 mm x 4.6 mm), 5µm and mobile phase comprised of Buffer (pH 2.5) and Acetonitrile in proportion of 50: 50 (v/v).The flow rate was 2.0ml/min and the eluent was monitored at 210nm.The selected chromatographic conditions were found to effectively quantitate Atazanavir and Ritonavir at retention time of about&nbsp; 3.5min&nbsp; and&nbsp; 9min respectively. Linearity were found to be in the range of 29.9792- 449.6885 µg/mL for Atazanavir and 9.9939 - 149.9089µg/ml for Ritonavir.The percentage recoveries of all the drugs were found to be 98.0-102.0%.The proposed method were found to be fast,specific,accurate,precise and reproducible and can be used for the estimation of Atazanavir and Ritonavir drug.</p> R. Rajesh Rakesh K Jat Copyright (c) 2023 2022-12-27 2022-12-27 9 6 13 20 ANTIOXIDANT POTENTIAL OF VARIOUS EXTRACTS OF COCCINA INDICA, SIDA CORDATA, MEDICAGO SATIVA AND WEDELIA TRILOBATA USING DPPH METHOD <p>Background - As an element safeguarding the body's health, antioxidants are crucial. Antioxidants may lower your chance of developing chronic diseases including cancer, Liver and heart disease, according to scientific research. The majority of the antioxidant substances in a regular diet come from plant sources and fall under several groups of substances with a wide range of physical and chemical characteristics.</p> <p>Objective - To evaluate the Antioxidant activity of the various extracts of <em>Coccina indica</em>, <em>Sida cordata</em>, <em>Medicago sativa</em> and . <em>Wedelia trilobata</em> leaves using 2, 2-Diphenyl-1-Picrylhydrazyl (DPPH) Method.</p> <p>Methods –</p> <p>The selected plant components are crushed into a fine powder, and this powder is then sieved through a specific number of sieve 40 to create a homogenous powder. Additionally, this powder has been tested in accordance with WHO guidelines. It was discovered that all of the measured parameters fell inside the defined ranges. All of the plant parts were extracted using pet ether, chloroform, ethanol, and aqueous after physicochemical evaluation.</p> <p>Results –</p> <p>In this study Antioxidant activity was performed by DPPH (1, 1diphenyl-2-picrylhydrazyl) radical scavenging method for different extracts of leaves of of <em>Coccinaindica</em>, <em>Sidacordata</em>, <em>Medicago sativa</em> and <em>Wedeliatrilobata</em>. plant species which showed that alcoholic extract of leaves of this plant on higher concentration possess better antioxidant potential when compare to reference standard ascorbic acid. They exhibited strong antioxidant DPPH radical scavenging activity with IC50 value of9.3 and 24.8 μg/ml for ascorbic acid and alcoholic leaves extract respectively. The absorbance for reducing power was found to be 0.0390, 0.0989 for ascorbic acid and alcoholic leaves extract respectively. The strongest antioxidant activity of ethanol extract could be due to the presence of flavonoids and phenols.</p> Mantry Piyush Dr. Jat K. Rakesh Copyright (c) 2023 2022-12-27 2022-12-27 9 6 21 27