Tropical Journal of Pharmaceutical and Life Sciences <p align="justify"><strong>Tropical Journal of Pharmaceutical and Life Sciences-TJPLS Journal (ISSN : 2349-9818) </strong>is a Scholarly Double-Blind Peer-reviewed international journal which promotes the original work in field of pharmaceutical and life sciences. Necessity is the mother of invention and invention arises from researches. Therefore promoting researchers is way to solving the problems of humanity. Pharmacy is the field which is for serving the mankind and to relieve it from suffering. TJPLS accepts original research papers as well as review articles in the field of Pharmaceutical and Life Sciences.</p> en-US (Tropical Journal of Pharmaceutical and Life Sciences) (Tropical Journal of Pharmaceutical and Life Sciences) Tue, 27 Feb 2024 06:47:42 +0530 OJS 60 Phytochemical screening and evaluation of the anti-venom effect of leaves extracts of Vitex negundo <p>The number of snake envenomation cases is estimated to be more than 5 million per year. Out of these cases, approximately 1,00,000 individuals experience severe complications. The objective of the current research is to investigate the effectiveness of local plant extracts from the western ghats of India in countering snake venom. &nbsp;The medicinal plant <em>Vitex negundo</em> has been traditionally used by healers in India to treat snakebite victims. Prior to injection, extract from the <em>Vitex negundo</em>&nbsp; &nbsp;plant was incubated at 37°C for 30 minutes. The study revealed that doses ranging from 0.15-0.17 mg of <em>Vitex negundo&nbsp; </em>&nbsp;extracts completely neutralized the lethal effects of <em>V. russelli</em> venom, while doses of 0.16-0.19 mg neutralized the lethal effects of Najanaja venom. In rats, the minimum edematic dose of the venom was found to be 4μg. Notably, significant inflammation was observed 1 hour after venom injection, with maximum inflammation occurring at 180 minutes. Furthermore, plant extracts administered at doses of 100mg/kg, 200mg/kg, and 400mg/kg exhibited significant activity compared to the control group. The minimum percentage inhibition was 29.13% and 27.1% at 100mg/kg, 58.18% and 57.21% at 240 minutes for 400mg/kg, and 60.89% for Vitex negundo&nbsp; &nbsp;with standard polyvalent antivenom. against V. Russelli and Najanaja venom, respectively.</p> Dinesh Jindal, Raghvendra S. Bhadauria Copyright (c) 2024 Tropical Journal of Pharmaceutical and Life Sciences Mon, 26 Feb 2024 00:00:00 +0530