NEUROPROTECTIVE ACTIVITY OF ACALYPHA WILKESIANA IN MANAGEMENT OF NEURODEGENERATIVE DISEASES
Keywords:
Alzheimer’s disease, Acalypha wilkesiana ( EELAW), Elevated Plus Maze.Abstract
To evaluate the neuroprotective activity of Ethanolic extract of leaves of Acalypha wilkesiana (EELAW) using Elevated Plus Maze in mice model. Neuroprotective activity in Alzheimer’s disease was assessed in mice by using Elevated Plus Maze. The present study was undertaken to establish the potential of EELAW as a memory enhancer. The elevated plus maze was employed to evaluate learning and memory parameters. Two doses (250 and 500 mg/kg, po.) of EELAW were administered for 8 successive days to mice. The 200 mg/kg dose of EELAW has significantly improved learning and memory in mice and also reversed the amnesia induced by diazepam (1 mg/kg ip) and scopolamine (0.4 mg/kg, ip). It is observed that scopolamine-induced amnesia was reversed, i.e. an enhancement/ improvement in memory was observed may be due to the facilitation of cholinergic transmission in the brain. Hence EELAW might prove to be a useful memory restorative agent in the treatment of dementia conditions seen in elderly persons. The underlying mechanism of action can be attributed to its antioxidant properties of the phytoconstituents present in the extract.
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Barbara Schmidt, David M. Ribnicky , Alexander Poulev,Sithes Logendra, William T. Cefalu, Ilya Raskin, A natural history of botanical therapeutics , Metabolism Clinical and Experimental 57,2008;suppl-1: S3-S9.
Raskin I, Ripoll C. Can an apple a day keep the doctor away? Curr Pharm Des 2004; 10:3419-29.
Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nat Rev Drug Discov 2005; 4:206-20.
Newman DJ, Cragg GM. Natural products from marine invertebrates and microbes as modulators of antitumor targets. Curr Drug Targets 2006; 7:279-304.
Butler MS. The role of natural product chemistry in drug discovery. J Nat Prod 2004; 67:2141-53.
Feher M, Schmidt JM. Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. J Chem Inf Comput Sci 2003; 43:218-27.
Lee ML, Schneider G. Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product–based combinatorial libraries. J Comb Chem 2001; 3:284-9.
Stahura FL, Godden JW, Xue L, Bajorath J. Distinguishing between natural products and synthetic molecules by descriptor Shannon entropy analysis and binary QSAR calculations. J Chem INF Comput Sci 2000; 40:1245-52.
Henkel T, Brunne RM, Muller H, Reichel F. Statistical investigation into the structural complementarity of natural products and synthetic compounds. Angew Chem 1999; 38:643-7.
Levites Koch MA, et al. Charting biologically relevant chemical space: a structural classification of natural products (SCONP). Proc Natl Acad Sci U S A 2005; 102:17272-7.
Ilya Raskin,David M.Ribnicky,Slavko Komarnytsky,Nebojsa Ilic,Alexander Poulev, Nikolai Borisjuk,Anita Brinker,Diego A.Moreno,Christophe Ripoll,Nir Yakoby, Joseph M.O’Neal,Teresa Cornwell,Ira Pastor and Bertold Fridlender ,Plants and human health in the twenty-first century, T R E N D S i n B i o t e ch n o l o g y. December 200; Vol.20: No.12.
Swerdlow J,. Plants That Heal, National Geographic Society , Nature’s Medicine,2000.
Pierpoint, W.S. (1994) Salicylic acid and its derivatives in plants: Medicines, metabolites and messenger molecules. Adv. Bot. Res. 20, 163–235
Business Communications Company, Inc. (1998) Plant-Derived Drugs: Products, Technologies and Applications. Study RB-121.
Cotran, R.S., Cumar, V., Collins,T.: Pathological basis of Pharmacology. Chapman & Hall international Thomson publishing company (1995).
Beal M.FOxidative damage in neurodegenerative diseases. Neuroscientist, 3: 21-2
Rang, H. P., Dale, M.M., Ritter, J.M., Moore, P.K.: Pharmacology, Churchill, Livingstone (2003).
Waldmeier P.C. and Tatton WG (2004), Interupting apoptosis in neurodegenerative disease: potential for effective therapy? DDT, 9: 210-218
Shete R V and Bodhankar S L (2010). Hemidesmus indicus: Evaluation of its nootropic effect in mice, International Journal of Pharma and Bio Sciences, 1(3) : 1-10
Robert K and Claudia K, Risk factors for Alzheimer’s disease. Neuro Science News 1(4): 27- 44, (1998).
Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, editors. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 9th Edition. New York: McGraw-Hill. (1996)
Parkinson’s disease, (2007) Thomas B and Beal M.F Human Molecular Genetics, 16- 2, R183–R194.
23.Hall ED(1995) Inhibition of lipid peroxidation in central nervous system trauma and ischemia.J.Neurol Sci. 134: 79-83
Lipton SA and Rosenberg PA (1994).Excitatory amino acids a final common pathway for neurologic disorders N.Engl. J. Med, 330: 626-632.
Lipton, S.A., and Rosenberg, P.A.: New Engl. J. Med., 330:613-622 (1994).
Steller,H.: Science., 267:1445-1449 (1995).
Vyawahare N.S. Ambikar D.B., Patil G.T. Kamble P.N. and Chitte N.S. (2008) Phytomedicines for neuroprotection, Electronic J. Pharma. Therapy, 1: 15-23
Sing S, Melkani GC, Gaur SPS, Agrawal V and Agrawal CG (1997). Oxidative stress and metabolid control in non-insulin dependent diabetes mellitus. Ind. J. Biochem. Biophys., 34: 512- 517
Zhang, D., Gengtao L., Jiangong S., Zhang, J.: J Ethnopharmacol. 104(1-2):250-256 (2006).
Peter Hill (2006) Medical news today.
Halliwell (1994) , Free radicals, antioxidants and human disease : curiosity or consequence? The Lancet, 344: 721-724
Cao G,Sofic E and Prior L (1997). Antioxidant and prooxidant behaviour of flavonoids: structure activity relationship. Free Rad. Bio. Med, 84-1: 91-94.
MorelI et al. (1993). Antioxidant and iron chelating activities of flavonoids catechin, quercetin, and diosmetin on iron loaded rat hepatocyte cultures. Biochem.Pharmacol. 45: 13-19
Pushpangadan P. Antioxidant approach to disease management and the role of ‘Rasayana’ herbs of Ayurveda. J Ethnopharmacol 99: 165-178, (2005).
Brahma SK and Debnath PK Therapeutic importance of Rasayana drugs with special reference to their multi-dimensional actions. Aryavaidyan 16: 160-163, (2003).
Samson A, Adze B, binda L, Wambebe L and Gamaniel K.(2001) Neuropharmacological effect of aqueous extract of Sphaeranhus senegalensis in mice. J.Ethnopharmcol, 78: 33
Nadkarni, K.M.: Indian Materia Medica Vol 1&II., Popular Prakashan Pvt. Ltd,Mumbai (1976).
Valery, L. F.: Stroke. 38:1734-1736 (2007).
Wasik, J.: Consumer’s digest. 75-79 (1999).
Esenberg, D.M., Kessler,R.F., Norlock, F.E., Calkins, D.R.,Delbanco, T.L.: New Engl. J.Med., 328: 246-252 (1993).
Sharma PV, Dravyaguna Vijnan, Medhya Varga, Chaukambha Bharati Academy, Varanasi. Hindi, (1987).
Govindadasa, Bhaisajyaratnavali, Varanasi, Chaukambha Sanskrita Academy, (1984).
Lolamba, Raj Vaidya Jivanam, Chaukambha Sanskrita Academy, Varanasi, Sanskrit, (1947).
Kirtikar K.R. and Basu B.D. Indian medicinal plants II edition, 1993, International Book Distributors Deharadun., 1090
Ambikar D.B., Harle U.N., Khandare R.A., Bore V.V. amd Vyawahare N.S (2009) Neuroprotective effect of hydroalcoholic extract of dried fruits of Trapa bispinosa Roxb on lipofuscinogenesis and fluorescence product in brain of D-galactose induced ageing accelerated mice. Indian Journal of Experimental Biology , 48: 378-38
Chatterji, N., Rastorgi, R.P., Dhar, M.L.: Indian J. Chem., 1: 212 (1963).
Gajare, K.A., Deshmukh,A.A., Pillai, M.M.: J.Cell TissueRes., 7(2):1167-1172 (2007).
Munch, G., Simm, A., Double, K.L., Riederer, P.: Alzheimer’sDiseaseRev, 1: 71- 74 (1996).
Mullarkey, C.J., Edelstein, D Brownlee, M.:Biochem. Biophys.Res.Commun.,173:932- 939 (1990).
Schmidt, A.M., Hori,O.,Chen, J.X.,Crandall, J.,Brett, J.,Yan, S.D., Stern, D.: J. Clin. Invest, 96(3): 1395-1403 (1995).
Hou, F.F., Hao, R., Chen, J.X., Li, J.F., Chem, P.Y.Schmidt,A.M.: J.Am. Soc.Nephrol, 15:1889- 1896(2004).
Deshmukh, A.A., Gajare, K.A., Pullajwar, V.S., Ruiker, A.A., Bule, and P.P.: J.Cell TissueRes., 6(2):757-761 (2006).
Jyoti, A., Sethi, P., Sharma, D.: J.Ethnopharmacol. 111(1):56-62 (2007).
Stahl, S.M.: Essential Psychopharmacology, CambridgeUniversity Press, (1998).
Vinutha,B., Prashanth,D., Salma,K., Sreeja,S.L., Pratiti, D., Padmaja, R., Radhika, S., Amita, A., Venkateshwarlu, K.,Deepak,M.: J. Ethnopharmacol., 109: 359– 363 (2007).
Dhuley, J.N.: PhytotherapyRes. 15:524– 528 (2001).
Trigunayat, A., Raghavendra, M., Singh, R.K., Bhattacharya, A.K.,Acharya, S.B.: J. Nat. Rem., 7(2):234-246 (2007).
VeerendraKumar, M.H., Gupta, and Y.K.: J. Ethnopharmacol., 79: 253–260 (2002).
Joshi, H., Parle, M.: .Ind J. Pharma Sci., 68(3): 364-365 (2006).
Vinutha,B., Prashanth,D., Salma,K., Sreeja,S.L., Pratiti, D., Padmaja, R., Radhika, S., Amita, A., Venkateshwarlu, K.,Deepak,M.: J. Ethnopharmacol., 109: 359– 363 (2007).
Shukla, S.D., Jain, S., Sharma, K., Bhatnagar, M.: Ind J.Expt.Bio. 38: 1007– 1013(2000).
62. Kirtikar, K.R., Basu, B.D., Indian medicinal plants, Vol III., International book distributors, Deharadun (1993).
Shukla, P.K., Khanna, V.K., Ali,M.M., Maurya, R., Khan,M.Y. RikhabCS.: HumanExpt.Toxicol.,25:187- 194 (2006).
Wang, L.C.H., Wang, B., Sum-Yan, N., Tze-fun L., LawrenceC.H.J.Ethnopharmacol, 103:103- 108 (2006).
Kennedy, D.O., Scholey,A.B.: Pharmacol. Biochem. Behav, 75:687–700 (2003).
Limpeanchob N, Jaipan S, Rattanakaruna S, Phrompittayarat W, Ingkaninan K. Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences and Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok65000,Thailand Journal of Ethnopharmacology 2008; 120: 112-117.
Manish K Pandit, Neuroprotective Properties of Some Indian Medicinal Plants, International Journal of Pharmaceutical & Biological Archives 2011; 2(5):1374-1379
Jin Sup Shima, Hyo Geun Kim., Mi Sun Jua. Effects of the hook of Uncaria rhynchophyllon neurotoxicity in the 6-hydroxydopamine model of Parkinson’s disease. Journal of Ethnopharmacology 2009: 126:361–365.
Ahmad .M., Saleem. S. Neuroprotective effects of Withania somnifera on 6-droxydopamine induced Parkinsonism in rats”. Hum Exp Toxicol.2005: 24(3):137-147.
Selkoe, D. J. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001:81, 741−766.
Hardy, J., Selkoe, D. J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002:297, 353−356.
Lee, V. M., Goedert, M., Trojanowski, J. Q. Neurodegenerative tauopathies. Annu Rev Neurosci.2001:24, 1121−1159.
Planel, E., Yasutake, K., Fujita, S. C., & Ishiguro, K. Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse. J Biol Chem. 2001:276, 34298−34306.
J. Nunan, D.H. Small, Regulation of APP cleavage by alpha-, beta- and gammasecretases, FEBS Lett. 2000:483, 6–10.
Singh O Khanam Z., Misra N., Srivastava M.K. Chamomile (Matricariachamomilla L.): An overview Pharmacognosy review. 2011; 5:9:82-95.
www.longwoodherbal.org/chamomile
Shipochliev T. Uterotonic action of extracts from a group of medicinal plants. Vet Med Nauki.1981; 18(4):94-8.
Kobayashi Y., Nakano Y., Inayama K., Sakai A., Kamiya T. Dietary intake of the flower extracts of German chamomile (Matricaria recutita L.) inhibited compound 48/80-induced itch-scratch responses in mice. Phytomedicine. 2003; 10:8:657-664.
Gupta V., Mittal P., Bansal P., Khokra S.L., Kaushik D. Pharmacological Potential of Matricaria recutita-A Review. IJPSDR. 2010; 21:12-16.
Berry M. Herbal products, chamomiles. Pharmaceutical journal.1995; 254:191-193.
Blumenthal M. The complete German commission E monographs therapeutics guide to herbal medicines. American botanical council. 1998; 107.
Nemecz G. Chamomile. US Pharmacist. 1998; 23:115-116.
Shipochliev T., Dimitrov A., Aleksandrova E. Anti-inflammatory action of a group of plant extracts] Vet Med Nauki.1981; 18:6:87-94.
Amy H. Moore, M.K. O’Banion, Neuroinflammationandanti-inflammatorytherapyfor Alzheimer’s disease. Advance drug discovery review, Elsevier
Chandan roy1 and shyamal kanti das2, role of moringa oleifera on brain electrical activity in colchicine induced experimental rat model of Alzheimer’s disease: possible involvement of antioxidants.International Journal of Current Pharmaceutical Research; 2013:Vol 5, Issue 4
Anil Kumar, Neha Seghal, Pattipati S. Naidu, Satyanaryana S.V. Padi, Richa Goyal,Colchicines- induced neurotoxicity as an animal model of sporadic dementia of Alzheimer’s type,pharmacological reports 2007;59:274-83.
B.Ahlemeyer and J. Krieglstein, Neuroprotective effects of Ginkgo biloba extract CMLS, Cell.Mol. Life Sci. 2003; 60:1779–1792
Silvia Mandel, Tamar Amit, Lydia Reznichenko, Orly Weinreb and Moussa B. H. Youdim Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders .Mol. Nutr Food Res. 2006; 50: 229–234.
M. Raghavendra, Rituparna Maiti, Shafalika Kumar, S. B. Acharya, Role of Ocimum sanctum in the experimental model of Alzheimer’s disease in rats
Ikewuchi CJ, Ikewuchi CC, Onyeike EN, Uwakwe AA. Nutritional potential of the leaves of Acalypha wilkesiana ‘Godseffiana’Muell Arg. Journal of Applied Sciences and Environmental Management. 2010;14(3)
Kingsley O, Marshall AA, Inegbenose II. Phytochemical, proximate, and elemental analysis of Acalypha wilkesiana leaves. Scientific Journal of Pure and Applied Sciences. 2013;2(9):323-31.
Gupta RK, Pradeepa MH. In vitro antioxidant and H+, K+-ATPase inhibition activities of Acalypha wilkesiana foliage extract. Journal of Pharmacy & Bioallied Sciences. 2013 Jul;5(3):214
Seebaluck R, Gurib-Fakim A, Mahomoodally F. Medicinal plants from the genus Acalypha (Euphorbiaceae)–A review of their ethnopharmacology and phytochemistry. Journal of ethnopharmacology. 2015 Jan 15;159:137-57
Owoyele BV, Okoye OC, Dolor RO, Oloruntola OP, Soladoye AO. Analgesic, anti-inflammatory, and antipyretic effects of the ethanol extract of Acalypha wilkesiana leave in rats. Nigerian Journal of Physiological Sciences. 2011;26(1).
Omage K, Azeke MA, Omage SO. Evaluation of the efficacy of Acalypha wilkesiana leaves in managing cardiovascular disease risk factors in rabbits exposed to salt-loaded diets. Clinical Phyto science. 2018 Dec;4(1):1-7
Iniaghe OM, Egharevba O, Oyewo EB. Effect of aqueous leaf extract of Acalypha wilkesiana on hematological parameters in male Wistar albino rats. British journal of pharmaceutical research. 2013 Jul 1;3(3):465
Oni MO, Ogungbite OC, Oguntuase SO, Bamidele OS, Ofuya TI. Inhibitory effects of oil extract of green Acalypha (Acalypha wilkesiana) on antioxidant and neurotransmitter enzymes in Callosobruchus maculatus. The Journal of Basic and Applied Zoology. 2019 Dec;80(1):1-3
Din WM, Chu J, Clarke G, Jin KT, Bradshaw TD, Fry JR, Wiart C. Antioxidant and cytoprotective effects of an ethanol extract of Acalypha wilkesiana var. macarena from Malaysia. Natural product communications. 2013 Mar;8(3):1934578X1300800325
Gupta RK, Pradeepa MH. In vitro antioxidant and H+, K+-ATPase inhibition activities of Acalypha wilkesiana foliage extract. Journal of Pharmacy & Bioallied Sciences. 2013 Jul;5(3):214
Adejoke OE, Paulinus NS, Omonigho IH. Chemical and phytochemical analyses of extracts from the leaves of Acalypha wilkesiana, “an herbal plant used for the treatment of various skin disorders”. Ann Sci Technol. 2020;5(2):40-8
Gotep JG, Agada GO, Gbise DS, Chollom S. Antibacterial activity of ethanolic extract of Acalypha wilkesiana leaves growing in Jos, Plateau State, Nigeria. Malaysian Journal of Microbiology. 2010;6(2):69-74.
Odoh UE, Ndubuokwu RI, Inya-Agha SI, Osadebe PO, Uzor PF, Ezejiofor M. Antidiabetic activity and phytochemical screening of Acalypha wilkesiana (Euphorbiaceae) Mull Arg. roots in alloxan-induced diabetic rats. Scientific Research and Essays. 2014 Apr 15;9(7):204-12.
Ikewuchi JC, Uwakwe AA, Onyeike EN, Ikewuchi CC. Hepatoprotective effect of an aqueous extract of the leaves of Acalypha wilkesiana'Godseffiana'Muell Arg (Euphorbiaceae) against carbon tetrachloride-induced liver injury in rats. EXCLI journal. 2011;10:280.
Antiemetic activity of Acalypha Fimbriata Schumach. & Thonn., Acalypha ornata Hochst., and Acalypha wilkesiana cv. godseffiana Muell Arg.
Effect of Acalypha wilkesiana Muell Arg on the Blood Pressure and Aorta Contractility of Salt-Loaded Rats.
Joshi H, Parle M. Brahmi rasayana improves learning and memory in mice. Evidence-Based Complementary and Altjdernative Medicine. 2006 Mar 1;3(1):79-85
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